Publications

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Schappe MS, Brinn PA, Joshi NR, Greenberg RS, Min S, Alabi AA, Zhang C, Liberles SD, "A vagal reflex evoked by airway closure", Nature (2024), 627: 830-838

Hamacher C, Degen R, Franke M, Switacz VK, Fleck D, Katreddi RR, Hernandez-Clavijo A, Strauch M, Horio N, Hachgenei E, Spehr J, Liberles, SD, Merhof D, Forni PE, Zimmer-Bensch G, Ben-Shaul Y, Spehr M, "A revised conceptual framework for mouse vomeronasal pumping and stimulus sampling", Current Biology (2024), 34, 1-16 

Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun J, "Structural basis of amine odorant perception by a mammal olfactory receptor", Nature (2023), 618: 193.

Lowenstein ED, Ruffault P, Aristotelis M, Osman KL, Li H, Greenberg RS, Thompson R, Song K, Dietrich S, Li X, Vladimirov N, Woehler, A, Brunet J, Zampieri N, Kuhn R, Liberles SD, Jia S, Lewin GR, Rajewsky N, Lever TE, Birchmeier C, "Prox2 and Runx3 vagal sensory neurons regulate esophageal motility", Neuron (2023), 111: 2184

Bin NR, Prescott SL, Horio N, Wang Y, Chiu IM, Liberles SD, "An airway-to-brain sensory pathway mediates influenza-induced sickness", (2023) Naturehttps://doi.org/10.1038/s41586-023-05796-0

Hayashi M, Kaye JA, Douglas ER, Joshi NR, Gribble FM, Reimann F, Liberles SD, "Enteroendocrine cells that differentially control feeding and gut motility". (2023) eLife, DOI: 10.7554/eLife.78512

 

Ran C, Boettcher JC, Kaye JA, Gallori CE, Liberles SD, "A brainstem map for visceral sensations", (2022) Nature, 609: 320–326 

 

Zhang C, Vincelette LK, Reimann F, Liberles SD, "A brainstem circuit for nausea suppression", (2022) Cell Reports, 39: 110953


Prescott SL and Liberles SD, "Internal senses of the vagus nerve", (2022) Neuron, 110: 579-599


Fei A, Wu W, Tan L, Tang C, Xu Z, Huo X, Bao H, Kong Y, Johnson M, Hartmann G, Talay M, Yang C, Riegler C, Herrera KJ, Engert F, Xie XS, Barnea G, Liberles SD, Yang H, Li Q, "Coordination of two enhancers drives expression of olfactory trace amine-associated receptors", (2021) Nature Communications 12, Article: 3798

 

Tao J, Campbell JN, Tsai LT, Wu C, Liberles SD, Lowell BB, "Highly selective brain-to-gut communication via genetically defined vagus neurons", (2021) Neuron, 109: 2106-2115

 

Oh Y, Lai JS, Min S, Huang H, Liberles SD, Ryoo HD, Suh GSB, "Periphery signals generated by Piezo-mediated stomach stretch and Neuromedin-mediated glucose load regulate the Drosophila brain nutrient sensor", (2021) Neuron, 109: 1979-1995

 

Horio N and Liberles SD, "Hunger enhances food odor attraction through a Neuropeptide Y spotlight," (2021) Nature, 592: 262-266

 

Min S, Oh Y, Verma P, Whitehead SC, Yapici N, Van Vactor D, Suh GSB, Liberles SD, "Control of feeding by Piezo-mediated gut mechanosensation in Drosophila," (2021) eLife10:e63049 

 

Zhang C, Kaye JA, Cai Z, Wang Y, Prescott SL, Liberles SD, "Area postrema cell types that mediate nausea-associated behaviors", (2021) Neuron, 109: 461-472

 

Prescott SL, Umans BD, Williams EK, Brust RD, Liberles SD, "An airway protection program revealed by sweeping genetic control of vagal afferents", (2020) Cell, 181, 574-589

 

Min S, Chang RB, Prescott SL, Beeler B, Joshi NR, Strochlic DE, Liberles SD, "Arterial Baroreceptors Sense Blood Pressure through Decorated Aortic Claws", (2019) Cell Reports, 29(8): 2192-2201

 

Li C, Navarrete J, Liang J, Lu C, Funderburk SC, Chang RB, Liberles SD, Olson DP, Krashes MJ, "Defined paraventricular hypothalamic populations exhibit differential responses contingent on caloric state", (2019) Cell Metabolism, 29: 681-694

 

Zeng W, Marshall KL, Min S, Daou I, Chapleau MW, Abboud FM, Liberles SD, and Patapoutian A, "PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex", (2018) Science, 362: 464-467

 

Osakada T, Ishii KK, Mori H, Eguchi R, Ferrero DM, Yoshihara Y, Liberles SD, Miyamichi K, Touhara K, "Sexual rejection via a vomeronasal receptor-triggered limbic circuit", (2018) Nature Communications, 9:4463

 

Umans BD and Liberles SD, "Neural sensing of organ volume", (2018) Trends in Neuroscience, 41: 911-924

 

Adams JM, Pei H, Sandoval DA, Seeley RJ, Chang RB, Liberles SD, and Olson DP, "Liraglutide modulates appetite and body weight via GLP-1R-expressing glutamatergic neurons", (2018) Diabetes, 67: 1538-1548

 

Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, and Chiu IM, "Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia", (2018) Nature Medicine, 24, 417–426

Nonomura K*, Woo S*, Chang RB*, Gillich A, Qiu Z, Francisco AG, Ranade SS, Liberles SD, and Patapoutian A, "Piezo2 senses airway stretch and mediates lung inflation-induced apnea", (2017) Nature, 541: 176-181, Co-corresponding authors.

 Lou S, Adam Y, Weinstein EN, Williams EK, Williams K, Parot V, Kavokine N, Liberles SD, Madisen L, Zeng H, and Cohen AE, "Genetically targeted all-optical electrophysiology with a transgenic Cre-dependent Optopatch mouse", (2016) Journal of Neuroscience, 36: 11059-11073

Williams EK*, Chang RB*, Strochlic DE*, Umans BD, Lowell BB, Liberles SD, "Sensory neurons that detect stretch and nutrients in the digestive system", (2016) Cell, 166, 209-221

Stowers L and Liberles SD, "State-dependent responses to sex pheromones in mouse", (2016) Current Opinion in Neurobiology, 38, 74-79

Li Q, Tachie-Baffour Y, Liu Z, Baldwin, MW, Kruse AC, Liberles SD, "Non-classical amine recognition evolved in a large clade of olfactory receptors", (2015) eLife, 10.7554/eLife.10441

Chang RB*, Strochlic DE*, Williams EK, Umans BD, Liberles SD, "Vagal sensory neuron subtypes that differentially control breathing", (2015) Cell, 161, 622-633

Vicuna L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R, "The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase", (2015) Nature Medicine, doi: 10.1038/nm.3852

Li Q and Liberles SD, "Aversion and attraction through olfaction", (2015) Current Biology, 25, R120-R129

Liberles SD, "Trace amine-associated receptors: ligands, neural circuits, and behaviors", (2015) Current Opinion in Neurobiology, 34, 1-7

Chiu IM, Barrett LB, Williams E, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman G, Roberson DP, Ghasemlous N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf CJ, "Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity", (2014) eLife, 10.7554/eLife.04660

Baldwin MW, Toda Y, Nakagita T, O'Connell MJ, Klasing KC, Misaka T, Edwards SV, Liberles SD. "Evolution of sweet taste perception in hummingbirds by transformation of the ancestral umami receptor", (2014) Science, 345, 929-933

Krashes MJ, Shah BP, Madara JC, Olson DP, Strochlic DE, Garfield AS, Vong L, Pei H, Watabe-Uchida M, Uchida N, Liberles SD, Lowell BB, "An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger", (2014) Nature, 507: 238-242

Liberles SD. "Mammalian pheromones", (2014) Annual Review of Physiology, 76:151-175

Ferrero DM, Moeller LM, Osakada T, Horio N, Li Q, Roy DS, Cichy A, Spehr M, Touhara K, Liberles SD. "A juvenile mouse pheromone inhibits sexual behavior through the vomeronasal system", (2013) Nature, 502: 368-371

Hussain, H*, Saraiva, LR*, Ferrero, DM*, Ahuja G, Krishna VS, Liberles, SD, Korsching, SI, "High affinity olfactory receptor for the death-associated odor cadaverine", (2013) PNAS, 110 (48): 19579-19584, Co-corresponding authors.

Ferrero DM and Liberles SD. "Animal behavior: shifting neural circuits with sex hormones", (2013) Current Biology, 23: R621-R623

Li Q, Korzan WJ, Ferrero DM, Chang RB, Roy DS, Buchi M, Lemon JK, Kaur A, Stowers L, Fendt M, and Liberles SD, "Synchronous evolution of an odor biosynthesis pathway and behavioral response", (2013), Current Biology, 23 (1), 11-20

Johnson, M.A., Tsai, L., Roy, D.S., Valenzuela, D.H., Mosley, C., Magklara, A., Lomvardas, S., Liberles, S.D., and Barnea, G., "Neurons expressing trace amine-associated receptors project to discrete glomeruli and constitute an olfactory subsystem", (2012), PNAS, 109 (33), 13410-13415

Ferrero, D.M., Wacker, D., Roque, M.A., Baldwin, M.W., Stevens, R.C., and Liberles, S.D., "Agonists for 13 Trace Amine-Associated Receptors Provide Insight into the Molecular Basis of Odor Selectivity", (2012), ACS Chemical Biology, 7 (7), 1184-1189

Ferrero, D.M., Lemon, J.K., Fluegge, D., Pashkovski, S.L., Korzan, W.J., Datta, S.R., Spehr, M., Fendt, M., and Liberles, S.D., "Detection and avoidance of a carnivore odor by prey", (2011), PNAS, 108 (27), 11235-11240

Ferrero, D.M., and Liberles, S.D., “The secret codes of mammalian scents”, (2010), WIREs System Biology and Medicine, 2 (1), 23-33

Liberles, S.D., “Trace amine-associated receptors are olfactory receptors in vertebrates”, (2009), Annals NY Academy of Sciences, 1170, 168-72

Liberles, S.D., Horowitz LF, Kuang D, Contos JJ, Wilson KL, Siltberg-Liberles J, Liberles DA, and Buck LB, “Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ”, (2009), PNAS, 106 (24), 9842-7

Liberles, S.D. and Buck, L.B., “A second class of chemosensory receptors in the olfactory epithelium”, (2006) Nature, 442 (7103), 645-650

Montmayeur, J.-P., Liberles, S.D., Matsunami, H., and Buck, L.B., "A candidate taste receptor gene near a sweet taste locus", (2001) Nature Neuroscience, 4 (5): 492-498

Liberles, S.D. and Schreiber, S.L., "Apoptosis-inducing natural products found in utero in pregnant mice", (2000) Chemistry and Biology, 7(5): 365-372

Borchardt, A., Liberles, S.D., Biggar, S.R., Crabtree, G.R., and Schreiber, S.L., “Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale”, (1997) Chemistry & Biology, 4(12): 961-968

Liberles, S.D., Diver, S.T., Austin, D.J., and Schreiber, S.L., “Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen”, (1997) PNAS, 94 (15): 7825-7830

Taveras A.G., et al., "Ras oncoprotein inhibitors:  the discovery of potent Ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex", (1997) Bioorganic & Medicinal Chemistry, 5, 125

Ganguly A.K., et al., "Detection and structural characterization of ras oncoprotein-inhibitor complexes by electrospray mass spectrometry", (1997) Bioorganic & Medicinal Chemistry, 5, 817

Ganguly A.K., et al., “Studies of the Ras-GDP and Ras-GTP noncovalent complexes by electrospray mass spectrometry”, (1993) Tetrahedron 49, 7985-7996